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 · Table shows the table consisting of the recorded IRPs Line IRPs with details are displayed as a plain text in lines For a loopback test with no hardware flow control marked red in Fig 2 3 below you connect pins 2 and 3 for RS 232 pins 4 to 8 and 5 to 9 for RS 422/485 For a loopback test with a hardware flow control marked blue in Fig 2 3 you connect pins 4 to 6 DTR/DSR

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 · 200 billion red blood cells RBCs IRPs also modulate the translation of the mRNAs that encode the erythroid specific ALAS2 enzyme involved in heme biosynthesis mitochondrial aconitase ACO2 and of the transcription factor HIF2α A single 3′ UTR IRE motif is present in the DMT1 mRNA but its mechanism of action is not fully resolved B FPN is subject to multilayered regulation in

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 · Concurrently the IRPs bind to IREs in the 3′ UTR of the TfR1 mRNA thereby protecting the message from degradation and enabling more TfR1 to be expressed on the cell membrane This effect in turn enables the cell to maximize its iron intake When cellular iron concentrations are high the IRPs do not bind to IREs thereby allowing translation of the ferritin mRNA to proceed and exposing


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